Phosphatases in the cellular response to DNA damage
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چکیده
منابع مشابه
Cellular metabolic response to DNA damage
DNA damage elicits a cellular signaling response that initiates cell cycle arrest and DNA repair. The metabolic response to DNA damage is largely unknown. Here we report a novel metabolic response to genotoxic stress. DNA damage triggers a critical block in the uptake of glutamine, a mitochondrial substrate essential for cellular proliferation. Sirtuins regulate both cellular metabolism and str...
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Eukaryotic cells are continuously threatened by unavoidable errors during normal DNA replication or various sources of genotoxic stresses that cause DNA damage or stalled replication. To maintain genomic integrity, cells have developed a coordinated signaling network, known as the DNA damage response (DDR). Following DNA damage, sensor molecules detect the presence of DNA damage and transmit si...
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For many years, the study of the regulation of the SOS network was complicated by both the complexities of the responses and the interrelationships of the key regulatory elements. However, recently the application of powerful genetic and molecular biological techniques has allowed us to gain a detailed picture of the regulation of this complex network. The network is now known to consist of mor...
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ژورنال
عنوان ژورنال: Cell Communication and Signaling
سال: 2010
ISSN: 1478-811X
DOI: 10.1186/1478-811x-8-27